Ontology highlight
ABSTRACT:
SUBMITTER: Lee NY
PROVIDER: S-EPMC9367457 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Lee Ning-Yuan NY Hum Melissa M Ong Pei-Yi PY Myint Matthew Khine MK Ong Enya H W EHW Low Kar-Perng KP Li Zheng Z Goh Boon-Cher BC Tay Joshua K JK Loh Kwok-Seng KS Chua Melvin L K MLK Lee Soo-Chin SC Khor Chiea-Chuen CC Lee Ann S G ASG
Cancers 20220728 15
The current understanding of genetic susceptibility factors for nasopharyngeal carcinoma (NPC) is still incomplete. To identify novel germline variants associated with NPC predisposition, we analysed whole-exome sequencing data from 119 NPC patients from Singapore with a family history of NPC and/or with early-onset NPC, together with 1337 Singaporean participants without NPC. Variants were prioritised and filtered by selecting variants with minor allele frequencies of <1% in both local control ...[more]