The expression pattern of Immune checkpoints after chemo/radiotherapy in the tumor microenvironment.

ABSTRACT: As a disease with the highest disease-associated burden worldwide, cancer has been the main subject of a considerable proportion of medical research in recent years, intending to find more effective therapeutic approaches with fewer side effects. Combining conventional methods with newer biologically based treatments such as immunotherapy can be a promising approach to treating different tumors. The concept of "cancer immunoediting" that occurs in the field of the tumor microenvironment (TME) is the aspect of cancer therapy that has not been at the center of attention. One group of the role players of the so-called immunoediting process are the immune checkpoint molecules that exert either co-stimulatory or co-inhibitory effects in the anti-tumor immunity of the host. It involves alteratio

SUBMITTER: Hassanian H 

PROVIDER: S-EPMC9367471 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature