A Systematic Review of Circulating Tumor Cells Clinical Application in Prostate Cancer Diagnosis.

ABSTRACT: The purpose of the review is to summarize the recent data on circulating tumor cells (CTC) use in clinical practice. We performed a systematic literature search using two databases (Medline and Scopus) over the past five years and the following terms: (CTC OR "circulating tumor cells" OR "liquid biopsy") AND prostate. The primary outcome was CTC predictive value for prostate cancer (PC) progression and survival. The secondary outcomes were the CTC predictive value for therapy response and the results of CTC detection depending on the assessment method. In metastatic PC, the CTC count showed itself to be a prognostic marker in terms of clinically important features, namely survival rates and response to treatment. CTC concentration was significantly associated with the overall survival and

SUBMITTER: Enikeev D 

PROVIDER: S-EPMC9367494 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature