Vitamin D, Th17 Lymphocytes, and Breast Cancer.

ABSTRACT: Vitamin D₃, which is well known to maintain calcium homeostasis, plays an important role in various cellular processes. It regulates the proliferation and differentiation of several normal cells, including immune and neoplastic cells, influences the cell cycle, and stimulates cell maturation and apoptosis through a mechanism dependent on the vitamin D receptor. The involvement of vitamin D₃ in breast cancer development has been observed in numerous clinical studies. However, not all studies support the protective effect of vitamin D₃ against the development of this condition. Furthermore, animal studies have revealed that calcitriol or its analogs may stimulate tumor growth or metastasis in some breast cancer models. It has been postulated that the effect o

SUBMITTER: Filip-Psurska B 

PROVIDER: S-EPMC9367508 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature