HMRP8-ATTAC Mice: A New Model for Conditional and Reversible Neutrophil Ablation.

ABSTRACT: Neutrophils are not only crucial immune cells for the neutralization of pathogens during infections, but they are also key players in tissue repair and cancer. Several methods are available to investigate the in vivo role of neutrophils in these conditions, including the depletion of neutrophils with neutralizing antibodies against Ly6G, or the blockade of neutrophil recruitment with CXCR2 inhibitors. A limited number of transgenic mouse models were generated that rely on the disruption of genes important for neutrophil development or on the injection of diphtheria toxin to induce neutrophil ablation. However, these methods have various limitations, including a lack of neutrophil specificity, a lack of long-term efficacy, or a lack of the ability to conditionally deplete neutrophils. There

SUBMITTER: Duits DEM 

PROVIDER: S-EPMC9367557 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature