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A Synopsis Clonal Hematopoiesis of Indeterminate Potential in Hematology.


ABSTRACT: Clonal hematopoiesis of indeterminate potential can be defined as genetic mutations that correlate in hematologic neoplasia such as myelodysplastic syndrome. Patients with cytopenia increasingly undergo molecular genetic tests of peripheral blood or bone marrow for diagnostic purposes. Recently, a new entity has been demarcated to lessen the risk of incorrect diagnoses of hematologic malignancies. This new entity is a potential precursor of myeloid diseases, analogous to monoclonal gammopathy of undetermined significance as a potential precursor of multiple myeloma.

SUBMITTER: Bou Zerdan M 

PROVIDER: S-EPMC9367563 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

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A Synopsis Clonal Hematopoiesis of Indeterminate Potential in Hematology.

Bou Zerdan Maroun M   Nasr Lewis L   Saba Ludovic L   Meouchy Paul P   Safi Nadine N   Allam Sabine S   Bhandari Jenish J   Chaulagain Chakra P CP  

Cancers 20220728 15


Clonal hematopoiesis of indeterminate potential can be defined as genetic mutations that correlate in hematologic neoplasia such as myelodysplastic syndrome. Patients with cytopenia increasingly undergo molecular genetic tests of peripheral blood or bone marrow for diagnostic purposes. Recently, a new entity has been demarcated to lessen the risk of incorrect diagnoses of hematologic malignancies. This new entity is a potential precursor of myeloid diseases, analogous to monoclonal gammopathy of  ...[more]

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