Transdiagnostic development of internalizing psychopathology throughout the life course up to age 45: a World Mental Health Surveys report.

ABSTRACT:

Background

Depressive and anxiety disorders are highly comorbid, which has been theorized to be due to an underlying internalizing vulnerability. We aimed to identify groups of participants with differing vulnerabilities by examining the course of internalizing psychopathology up to age 45.

Methods

We used data from 24158 participants (aged 45+) in 23 population-based cross-sectional World Mental Health Surveys. Internalizing disorders were assessed with the Composite International Diagnostic Interview (CIDI). We applied latent class growth analysis (LCGA) and investigated the characteristics of identified classes using logistic or linear regression.

Results

The best-fitting LCGA solution identified eight classes: a healthy class (81.9%), three childhood-onset classes

SUBMITTER: de Vries YA 

PROVIDER: S-EPMC9367642 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature