Association of sodium voltage-gated channel genes polymorphisms with epilepsy risk and prognosis in the Saudi population.

ABSTRACT:

Background

Epilepsy is a heterogeneous complex condition that involve the human brain. Genetic predisposition to epilepsy is a fundamental factor of the disorder aetiology. The sodium voltage-gated channel (SCN) genes variants are critical biomarker for the epilepsy development and progression. In this study, we aimed to investigate the association of several SNCs genetic polymorphisms with epilepsy risk and their intrudance of the disease prognosis.

Methods

Blood samples were withdrawn from 296 Epilepsy patients in addition to 293 healthy matched participants prior to DNA extraction. PCR-sequencing was used for genotyping analysis. Genotyping outputs were then statistically analysed for genotype/phenotype evaluation.

Results

Within SCN1A gene we found that the rs6432

SUBMITTER: Alghamdi MA 

PROVIDER: S-EPMC9367647 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature