Metabolic and pharmacological profiling of Penicillium claviforme by a combination of experimental and bioinformatic approaches.

ABSTRACT:

Background

Penicillium produces a wide range of structurally diverse metabolites with significant pharmacological impacts in medicine and agriculture. For the first time, a complete metabolome of Penicillium claviforme (P. claviforme) (FBP-DNA-1205) was studied alongside pharmacological research in this study.

Methods

The metabolic profile of P. claviforme fermented on Potato Dextrose Broth (PDB) was investigated in this work. The complete metabolomics studies of fungus were performed using GC-MS and LC-MS-QTOF techniques. An in vitro model was utilised to study the cytotoxic and antioxidant activities, while an in vivo model was employed to investigate the antinociceptive and acute toxicity activities. Molecular Operating Environmen

SUBMITTER: Ali Shah Z 

PROVIDER: S-EPMC9367661 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature