Identification of Biomarkers Related to M2 Macrophage Infiltration in Alzheimer's Disease.

ABSTRACT: Many studies have demonstrated that neuroinflammation contributes to the onset and development of Alzheimer's disease (AD). The infiltration of immune cells in the brain was observed in AD. The purpose of the present study was to verify potential mechanisms and screen out biomarkers related to immune infiltration in AD. We collected the expression profiling datasets of AD patients and healthy donors from the NCBI's Gene Expression Omnibus (GEO) database. We confirmed that immune-related mechanisms were involved in AD using differentially expressed genes analysis and functional enrichment analysis. We then found that M2 macrophage infiltration was most positively correlated with AD according to the CIBERSORT algorithm and a weighted gene co-expression network analysis (WGCNA). TLR2,

SUBMITTER: Lin C 

PROVIDER: S-EPMC9367736 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature