ATP-Sensitive Potassium Channels in Migraine: Translational Findings and Therapeutic Potential.

ABSTRACT: Globally, migraine is a leading cause of disability with a huge impact on both the work and private life of affected persons. To overcome the societal migraine burden, better treatment options are needed. Increasing evidence suggests that ATP-sensitive potassium (K_ATP) channels are involved in migraine pathophysiology. These channels are essential both in blood glucose regulation and cardiovascular homeostasis. Experimental infusion of the K_ATP channel opener levcromakalim to healthy volunteers and migraine patients induced headache and migraine attacks in 82-100% of participants. Thus, this is the most potent trigger of headache and migraine identified to date. Levcromakalim likely induces migraine via dilation of cranial arteries. However, other neuronal mechanisms

SUBMITTER: Clement A 

PROVIDER: S-EPMC9367966 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature