Low Interleukin-12 Levels concerning Severe Malaria: A Systematic Review and Meta-Analysis.

ABSTRACT: Although many studies have investigated the role of interleukin (IL)-12 cytokine in the pathogenesis of severe malaria, these studies were based on a limited number of participants, possibly affecting their outcomes. We analyzed the difference in IL-12 levels between patients with severe and uncomplicated malaria through a meta-analysis. A systematic review was conducted following the Cochrane Handbook for Systematic Reviews of Interventions and was reported according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses statement. Systematic literature searches were performed between 20 February and 2 March, 2022 in PubMed, Scopus, and Embase to identify studies reporting IL-12 levels in patients with severe and uncomplicated malaria. The quality of included studies wa

SUBMITTER: Wilairatana P 

PROVIDER: S-EPMC9368085 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature