Iridium-Catalyzed Borylation of 6-Fluoroquinolines: Access to 6-Fluoroquinolones.

ABSTRACT: The Ir-catalyzed C-H borylation of fluoroquinolines has been realized. The quinoline boronic ester formed undergoes a range of important transformations of relevance to medicinal chemistry. Judicious choice of the substituent at C4 on the quinoline facilitated the unmasking of a fluoroquinolone─the core structure of many antibiotics.

SUBMITTER: Hickey A 

PROVIDER: S-EPMC9368603 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature