Identification of pyroptosis-related subtypes and establishment of prognostic model and immune characteristics in asthma.

ABSTRACT:

Background

Although studies have shown that cell pyroptosis is involved in the progression of asthma, a systematic analysis of the clinical significance of pyroptosis-related genes (PRGs) cooperating with immune cells in asthma patients is still lacking.

Methods

Transcriptome sequencing datasets from patients with different disease courses were used to screen pyroptosis-related differentially expressed genes and perform biological function analysis. Clustering based on K-means unsupervised clustering method is performed to identify pyroptosis-related subtypes in asthma and explore biological functional characteristics of poorly controlled subtypes. Diagnostic markers between subtypes were screened and validated using an asthma mouse model. The infiltration of immune cells in

SUBMITTER: Yang F 

PROVIDER: S-EPMC9368761 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature