Distinct Longitudinal Changes in Immunoglobulin G N-Glycosylation Associate with Therapy Response in Chronic Inflammatory Diseases.

ABSTRACT: Immunosuppressants and biologicals are widely used therapeutics for various chronic inflammatory diseases (CID). To gain more detailed insight into their downstream effects, we examined their impact on serum immunoglobulin G (IgG) glycosylation. We analyzed IgG subclass-specific fragment crystallizable (Fc) N-glycosylation in patients suffering from various CID using the LC-MS approach. Firstly, we compared IgG Fc N-glycosylation between 128 CID patients and 204 healthy controls. Our results replicated previously observed CID-related decrease in IgG Fc galactosylation (adjusted p-value range 1.70 × 10^-2-5.95 × 10^-22) and sialylation (adjusted p-value range 1.85 × 10^-2-1.71 × 10^-18). Secondly, to assess changes in IgG Fc N-glycosylat

SUBMITTER: Stambuk J 

PROVIDER: S-EPMC9368836 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature