NIR-Triggered Generation of Reactive Oxygen Species and Photodynamic Therapy Based on Mesoporous Silica-Coated LiYF₄ Upconverting Nanoparticles.

ABSTRACT: To date, the increase in reactive oxygen species (ROS) production for effectual photodynamic therapy (PDT) treatment still remains challenging. In this study, a facile and effective approach is utilized to coat mesoporous silica (mSiO₂) shell on the ligand-free upconversion nanoparticles (UCNPs) based on the LiYF₄ host material. Two kinds of mesoporous silica-coated UCNPs (UCNP@mSiO₂) that display green emission (doped with Ho³⁺) and red emission (doped with Er³⁺), respectively, were successfully synthesized and well characterized. Three photosensitizers (PSs), merocyanine 540 (MC 540), rose bengal (RB), and chlorin e6 (Ce6), with the function of absorption of green or red emission, were selected and loaded into the mSiO₂ sh

SUBMITTER: Ho TH 

PROVIDER: S-EPMC9368848 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature