Salmonella Regulator STM0347 Mediates Flagellar Phase Variation via Hin Invertase.

ABSTRACT: Salmonella enterica is one of the most important food-borne pathogens, whose motility and virulence are highly related to flagella. Flagella alternatively express two kinds of surface antigen flagellin, FliC and FljB, in a phenomenon known as flagellar phase variation. The molecular mechanisms by which the switching orientation of the Hin-composed DNA segment mediates the expression of the fljBA promoter have been thoroughly illustrated. However, the precise regulators that control DNA strand exchange are barely understood. In this study, we found that a putative response regulator, STM0347, contributed to the phase variation of flagellin in S. Typhimurium. With quantitative proteomics and secretome profiling, a lack of STM0347 was confirmed to induce the transformatio

SUBMITTER: Wang H 

PROVIDER: S-EPMC9368917 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature