Unraveling the Role of Histone Variant CENP-A and Chaperone HJURP Expression in Thymic Epithelial Neoplasms.

ABSTRACT:

Background

Recent advances demonstrate the role of chromatin regulators, including histone variants and histone chaperones, in cancer initiation and progression.

Methods

Histone H3K4me3, histone variant centromere protein (CENP-A) and histone chaperones Holliday junction recognition protein (HJURP) as well as DAXX expression were examined immunohistochemically in 95 thymic epithelial tumor (TET) specimens. Our results were compared with the expression profile of DAXX, HJURP and CENP-A in gene expression profiling interactive analysis (GEPIA2).

Results

The lymphocyte-poor B3- and C-type TETs were more frequently DAXX negative (p = 0.043). B3 and C-Type TETs showed higher cytoplasmic and nuclear CENP-A (p = 0.007 and p = 0.002) and higher cytoplasmi

SUBMITTER: Levidou G 

PROVIDER: S-EPMC9368969 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature