The Roles of Histone Post-Translational Modifications in the Formation and Function of a Mitotic Chromosome.

ABSTRACT: During mitosis, many cellular structures are organized to segregate the replicated genome to the daughter cells. Chromatin is condensed to shape a mitotic chromosome. A multiprotein complex known as kinetochore is organized on a specific region of each chromosome, the centromere, which is defined by the presence of a histone H3 variant called CENP-A. The cytoskeleton is re-arranged to give rise to the mitotic spindle that binds to kinetochores and leads to the movement of chromosomes. How chromatin regulates different activities during mitosis is not well known. The role of histone post-translational modifications (HPTMs) in mitosis has been recently revealed. Specific HPTMs participate in local compaction during chromosome condensation. On the other hand, HPTMs are involved in CENP-A inco

SUBMITTER: Andonegui-Elguera MA 

PROVIDER: S-EPMC9368973 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature