Identification of Myocardial Insulin Resistance by Using Liver Tests: A Simple Approach for Clinical Practice.

ABSTRACT:

Background

We report that myocardial insulin resistance (mIR) occurs in around 60% of patients with type 2 diabetes (T2D) and was associated with higher cardiovascular risk in comparison with patients with insulin-sensitive myocardium (mIS). These two phenotypes (mIR vs. mIS) can only be assessed using time-consuming and expensive methods. The aim of the present study is to search a simple and reliable surrogate to identify both phenotypes.

Methods

Forty-seven patients with T2D underwent myocardial [18F]FDG PET/CT at baseline and after a hyperinsulinemic-euglycemic clamp (HEC) to determine mIR were prospectively recruited. Biochemical assessments were performed before and after the HEC. Baseline hepatic steatosis index and index of hepatic fibrosis (FIB-4) were calculated. F

SUBMITTER: Herance JR 

PROVIDER: S-EPMC9369008 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature