Sex-Dependent Regulation of Placental Oleic Acid and Palmitic Acid Metabolism by Maternal Glycemia and Associations with Birthweight.

ABSTRACT: Pregnancy complications such as maternal hyperglycemia increase perinatal mortality and morbidity, but risks are higher in males than in females. We hypothesized that fetal sex-dependent differences in placental palmitic-acid (PA) and oleic-acid (OA) metabolism influence such risks. Placental explants (n = 22) were incubated with isotope-labeled fatty acids (¹³C-PA or ¹³C-OA) for 24 or 48 h and the production of forty-seven ¹³C-PA lipids and thirty-seven ¹³C-OA lipids quantified by LCMS. Linear regression was used to investigate associations between maternal glycemia, BMI and fetal sex with ¹³C lipids, and between ¹³C lipids and birthweight centile. Placental explants from females showed greater incorporation of

SUBMITTER: Watkins OC 

PROVIDER: S-EPMC9369035 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature