Electron Attachment to 5-Fluorouracil: The Role of Hydrogen Fluoride in Dissociation Chemistry.

ABSTRACT: We investigate dissociative electron attachment to 5-fluorouracil (5-FU) employing a crossed electron-molecular beam experiment and quantum chemical calculations. Upon the formation of the 5-FU^- anion, 12 different fragmentation products are observed, the most probable dissociation channel being H loss. The parent anion, 5-FU^-, is not stable on the experimental timescale (~140 µs), most probably due to the low electron affinity of FU; simple HF loss and F^- formation are seen only with a rather weak abundance. The initial dynamics upon electron attachment seems to be governed by hydrogen atom pre-dissociation followed by either its full dissociation or roaming in the vicinity of the molecule, recombining eventually into the HF molecule. When the HF molecule

SUBMITTER: Arthur-Baidoo E 

PROVIDER: S-EPMC9369043 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature