Effective Optical Image Assessment of Cellulose Paper Immunostrips for Blood Typing.

ABSTRACT: Novel high-performance biosensing devices, based on a microporous cellulose matrix, have been of great interest due to their high sensitivity, low cost, and simple operation. Herein, we report on the design and testing of portable paper-based immunostrips (IMS) for in-field blood typing in emergencies requiring blood transfusion. Cellulose fibrils of a paper membrane were functionalized with antibodies via supramolecular interactions. The formation of hydrogen bonds between IgM pentamer and cellulose fibers was corroborated using quantum mechanical calculations with a model cellulose chain and a representative amino acid sequence. In the proposed immunostrips, paper with a pore size of 3 µm dia. was used to enable functionalization of its channels with antibody molecules while blocking the

SUBMITTER: Ratajczak K 

PROVIDER: S-EPMC9369064 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature