Platelet Lipidome Fingerprint: New Assistance to Characterize Platelet Dysfunction in Obesity.

ABSTRACT: Obesity is associated with a pro-inflammatory and pro-thrombotic state that supports atherosclerosis progression and platelet hyper-reactivity. During the last decade, the platelet lipidome has been considered a treasure trove, as it is a source of biomarkers for preventing and treating different pathologies. The goal of the present study was to determine the lipid profile of platelets from non-diabetic, severely obese patients compared with their age- and sex-matched lean controls. Lipids from washed platelets were isolated and major phospholipids, sphingolipids and neutral lipids were analyzed either by gas chromatography or by liquid chromatography coupled to mass spectrometry. Despite a significant increase in obese patient's plasma triglycerides, there were no significant differences

SUBMITTER: Chicanne G 

PROVIDER: S-EPMC9369067 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature