Validated Growth Rate-Dependent Regulation of Lipid Metabolism in Yarrowia lipolytica.

ABSTRACT: Given the strong potential of Yarrowia lipolytica to produce lipids for use as renewable fuels and oleochemicals, it is important to gain in-depth understanding of the molecular mechanism underlying its lipid accumulation. As cellular growth rate affects biomass lipid content, we performed a comparative proteomic analysis of Y. lipolytica grown in nitrogen-limited chemostat cultures at different dilution rates. After confirming the correlation between growth rate and lipid accumulation, we were able to identify various cellular functions and biological mechanisms involved in oleaginousness. Inspection of significantly up- and downregulated proteins revealed nonintuitive processes associated with lipid accumulation in this yeast. This included proteins related to endoplasmic r

SUBMITTER: Poorinmohammad N 

PROVIDER: S-EPMC9369070 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature