Identification of Novel Regulators of Radiosensitivity Using High-Throughput Genetic Screening.

ABSTRACT: The biological impact of ionizing radiation (IR) on humans depends not only on the physical properties and absorbed dose of radiation but also on the unique susceptibility of the exposed individual. A critical target of IR is DNA, and the DNA damage response is a safeguard mechanism for maintaining genomic integrity in response to the induced cellular stress. Unrepaired DNA lesions lead to various mutations, contributing to adverse health effects. Cellular sensitivity to IR is highly correlated with the ability of cells to repair DNA lesions, in particular coding sequences of genes that affect that process and of others that contribute to preserving genomic integrity. However, accurate profiling of the molecular events underlying individual sensitivity requires techniques with sensitive re

SUBMITTER: Tamaddondoust RN 

PROVIDER: S-EPMC9369104 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature