Systematic Review: Drug Repositioning for Congenital Disorders of Glycosylation (CDG).

ABSTRACT: Advances in research have boosted therapy development for congenital disorders of glycosylation (CDG), a group of rare genetic disorders affecting protein and lipid glycosylation and glycosylphosphatidylinositol anchor biosynthesis. The (re)use of known drugs for novel medical purposes, known as drug repositioning, is growing for both common and rare disorders. The latest innovation concerns the rational search for repositioned molecules which also benefits from artificial intelligence (AI). Compared to traditional methods, drug repositioning accelerates the overall drug discovery process while saving costs. This is particularly valuable for rare diseases. AI tools have proven their worth in diagnosis, in disease classification and characterization, and ultimately in therapy discovery in r

SUBMITTER: Brasil S 

PROVIDER: S-EPMC9369176 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature