Relationship between Serum Ferritin and Outcomes in β-Thalassemia: A Systematic Literature Review.

ABSTRACT: Among the difficulties of living with β-thalassemia, patients frequently require blood transfusions and experience iron overload. As serum ferritin (SF) provides an indication of potential iron overload, we conducted a systematic literature review (SLR) to assess whether SF levels are associated with clinical and economic burden and patient-reported outcomes (PROs). The SLR was conducted on 23 April 2020 and followed by analysis of the literature. Dual-screening was performed at the title, abstract, and full-text levels using predefined inclusion and exclusion criteria. Ten studies identified by the SLR were eligible for inclusion in the analysis. Seven studies were conducted in Europe, and most were prospective or retrospective in design. The patient populations had a median age of 20.7-4

SUBMITTER: Shah F 

PROVIDER: S-EPMC9369259 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature