New Imaging Modality of COVID-19 Pneumonia Developed on the Basis of Alzheimer's Disease Research.

ABSTRACT: Viral pneumonia caused by highly infectious SARS-CoV-2 poses a higher risk to older people and those who have underlying health conditions, including Alzheimer's disease. In this work we present newly designed tacrine-based radioconjugates with physicochemical and biological properties that are crucial for the potential application as diagnostic radiopharmaceuticals. A set of ten tacrine derivatives was synthesized, labelled with gallium-68 and fully characterized in the context of their physicochemical properties. Based on these results, the final two most promising radioconjugates, [⁶⁸Ga]Ga-NODAGA-Bn-NH(CH₂)₉Tac and [⁶⁸Ga]Ga-THP-NH(CH₂)₉Tac, were selected for biodistribution studies. The latter compound was proven to be a

SUBMITTER: Kozminski P 

PROVIDER: S-EPMC9369300 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature