PARP Inhibitors: Clinical Limitations and Recent Attempts to Overcome Them.

ABSTRACT: PARP inhibitors are the first clinically approved drugs that were developed based on synthetic lethality. PARP inhibitors have shown promising outcomes since their clinical applications and have recently been approved as maintenance treatment for cancer patients with BRCA mutations. PARP inhibitors also exhibit positive results even in patients without homologous recombination (HR) deficiency. Therapeutic effects were successfully achieved; however, the development of resistance was unavoidable. Approximately 40-70% of patients are likely to develop resistance. Here, we describe the mechanisms of action of PARP inhibitors, the causes of resistance, and the various efforts to overcome resistance. Particularly, we determined the survival probability of cancer patients according to the expres

SUBMITTER: Kim D 

PROVIDER: S-EPMC9369301 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature