Examination of Intracellular GPCR-Mediated Signaling with High Temporal Resolution.

ABSTRACT: The GTP-binding protein-coupled receptors (GPCRs) play important roles in physiology and neuronal signaling. More than a thousand genes, excluding the olfactory receptors, have been identified that encode these integral membrane proteins. Their pharmacological and functional properties make them fascinating targets for drug development, since various disease states can be treated and overcome by pharmacologically addressing these receptors and/or their downstream interacting partners. The activation of the GPCRs typically causes transient changes in the intracellular second messenger concentrations as well as in membrane conductance. In contrast to ion channel-mediated electrical signaling which results in spontaneous cellular responses, the GPCR-mediated metabotropic signals operate at a

SUBMITTER: Gruteser N 

PROVIDER: S-EPMC9369311 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature