Distinct Roles of Estrogen Receptors in the Regulation of Vitellogenin Expression in Orange-Spotted Grouper (Epinephelus coioides).

ABSTRACT: During their breeding season, estrogen induces vitellogenin (VTG) production in the liver of teleost fish through estrogen receptors (ERs) that support oocyte vitellogenesis. There are at least three ER subtypes in teleost fish, but their roles in mediating E₂-induced VTG expression have yet to be ascertained. In this study, we investigated the expression of vtgs and ers in the liver of orange-spotted grouper (Epinephelus coioides). Their expression levels were significantly increased in the breeding season and were upregulated by an estradiol (E₂) injection in female fish, except for the expression of erβ1. The upregulation of vtgs, erα and erβ2 by E₂ was also observed in primary hepatocytes, but these stimu

SUBMITTER: Ye Z 

PROVIDER: S-EPMC9369318 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature