Structural Evolution of Delta (B.1.617.2) and Omicron (BA.1) Spike Glycoproteins.

ABSTRACT: The vast amount of epidemiologic and genomic data that were gathered as a global response to the COVID-19 pandemic that was caused by SARS-CoV-2 offer a unique opportunity to shed light on the structural evolution of coronaviruses and in particular on the spike (S) glycoprotein, which mediates virus entry into the host cell by binding to the human ACE2 receptor. Herein, we carry out an investigation into the dynamic properties of the S glycoprotein, focusing on the much more transmissible Delta and Omicron variants. Notwithstanding the great number of mutations that have accumulated, particularly in the Omicron S glycoprotein, our data clearly showed the conservation of some structural and dynamic elements, such as the global motion of the receptor binding domain (RBD). However, our studie

SUBMITTER: Prandi IG 

PROVIDER: S-EPMC9369368 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature