Development of Fenofibrate/Randomly Methylated β-Cyclodextrin-Loaded Eudragit^® RL 100 Nanoparticles for Ocular Delivery.

ABSTRACT: Fenofibrate (FE) has been shown to markedly reduce the progression of diabetic retinopathy and age-related macular degeneration in clinical trials and animal models. Owing to the limited aqueous solubility of FE, it may hamper ocular bioavailability and result in low efficiency to treat such diseases. To enhance the solubility of FE, water-soluble FE/cyclodextrin (CD) complex formation was determined by a phase-solubility technique. Randomly methylated-β-CD (RMβCD) exhibited the best solubility and the highest complexation efficiency (CE) for FE. Additionally, water-soluble polymers (i.e., hydroxypropyl methyl cellulose and polyvinyl alcohol [PVA]) enhanced the solubility of FE/RMβCD complexes. Solid- and solution-state characterizations were performed to elucidate and confirm the formatio

SUBMITTER: Khin SY 

PROVIDER: S-EPMC9370055 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature