Sex-Gender Differences in Adult Coeliac Disease at Diagnosis and Gluten-Free-Diet Follow-Up.

ABSTRACT: Coeliac disease (CD) is an immune-mediated enteropathy triggered by gluten ingestion. At CD diagnosis, gender differences have been previously reported, but data regarding follow-up are scant. We investigated gender differences in CD adult patients both at the time of diagnosis and at follow-up after the start of the gluten-free diet (GFD). This is a longitudinal cohort study on adult CD patients diagnosed between 2008 and 2019. Clinical, biochemical, and histological data were assessed and compared between males and females. At diagnosis, female gender was significantly associated with signs of malabsorption (OR 3.39; 95% CI: 1.4-7.9), longer duration of symptoms and/or signs before the diagnosis (OR 3.39; 95% CI: 1.5-7.5), heartburn (OR 2.99; 95% CI: 1.1-8.0), dyspepsia (OR 2.70; 95% CI:

SUBMITTER: Galli G 

PROVIDER: S-EPMC9370199 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature