Comparative Effects of Allulose, Fructose, and Glucose on the Small Intestine.

ABSTRACT: Despite numerous studies on the health benefits of the rare sugar allulose, its effects on intestinal mucosal morphology and function are unclear. We therefore first determined its acute effects on the small intestinal transcriptome using DNA microarray analysis following intestinal allulose, fructose and glucose perfusion in rats. Expression levels of about 8-fold more genes were altered by allulose compared to fructose and glucose perfusion, suggesting a much greater impact on the intestinal transcriptome. Subsequent pathway analysis indicated that nutrient transport, metabolism, and digestive system development were markedly upregulated, suggesting allulose may acutely stimulate these functions. We then evaluated whether allulose can restore rat small intestinal structure and function w

SUBMITTER: Suzuki T 

PROVIDER: S-EPMC9370476 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature