A Comparison of the Impact of Restrictive Diets on the Gastrointestinal Tract of Mice.

ABSTRACT: The rate of gut inflammatory diseases is growing in modern society. Previously, we showed that caloric restriction (CR) shapes gut microbiota composition and diminishes the expression of inflammatory factors along the gastrointestinal (GI) tract. The current project aimed to assess whether prominent dietary restrictive approaches, including intermittent fasting (IF), fasting-mimicking diet (FMD), and ketogenic diet (KD) have a similar effect as CR. We sought to verify which of the restrictive dietary approaches is the most potent and if the molecular pathways responsible for the impact of the diets overlap. We characterized the impact of the diets in the context of several dietary restriction-related parameters, including immune status in the GI tract; microbiota and its metabolites; bile

SUBMITTER: Gregor A 

PROVIDER: S-EPMC9370610 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature