Mechanism of the Micellar Solubilization of Curcumin by Mixed Surfactants of SDS and Brij35 via NMR Spectroscopy.

ABSTRACT: The micellar solubilization mechanism of curcumin by mixed surfactants of SDS and Brij35 was investigated at the molecular scale by NMR spectroscopy. Through the investigation of the micelle formation process, types and structures of mixed micelles and solubilization sites, the intrinsic factors influencing the solubilization capacity were revealed. For systems with α_SDS = 0.5 and 0.2, the obtained molar solubilization ratios (MSRs) are consistent with the MSR_ideal values. However, for α_SDS = 0.8, the solubilization capacity of curcumin is weakened compared to the MSR_ideal. Furthermore, only one single mixed SDS/Brij35 micelles are formed for α_SDS = 0.5 and 0.2. However, for α_SDS = 0.8, there are separate SDS-rich and Brij35

SUBMITTER: Zhan X 

PROVIDER: S-EPMC9370735 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature