Antibacterial Activity of Aureonuclemycin Produced by Streptomyces aureus Strain SPRI-371.

ABSTRACT: Actinomycetes play a vital role as one of the most important natural resources for both pharmaceutical and agricultural applications. The actinomycete strain SPRI-371, isolated from soil collected in Jiangsu province, China, was classified as Streptomyces aureus based on its morphological, physiological, biochemical and molecular biological characteristics. Its bacterial activity metabolites were identified as aureonuclemycin (ANM), belonging to adenosine derivatives with the molecular formula C₁₆H₁₉N₅O₉ for ANM A and C₁₀H₁₃N₅O₃ for ANM B. Simultaneously, the industrial fermentation process of a mutated S. aureus strain SPRI-371 was optimized in a 20 m³ fermentation tank, featur

SUBMITTER: Wang W 

PROVIDER: S-EPMC9370760 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature