Salt-Sensitive Ileal Microbiota Plays a Role in Atrial Natriuretic Peptide Deficiency-Induced Cardiac Injury.

ABSTRACT: Atrial natriuretic peptide (ANP) activity deficiency contributes to salt-sensitive hypertension in humans and mice. However, the role of ileal microbiota in salt sensitivity in ANP deficiency-related cardiac injury has not been investigated yet. This study used ANP^-/- mice to analyze the role of the salt-sensitive ileal microbiome on cardiac injury. ANP^-/- mice showed an increase in blood pressure (BP), the heart weight/body weight (HW/BW) ratio, and cardiac hypertrophy compared with wild-type (WT) mice. ANP deficiency did not impact the histological structure but reduced occludin expression in the ileum. Antibiotics significantly relieved BP and cardiac hypertrophy in ANP^-/- mice. A high-salt diet (HSD) increased BP, the HW/BW ratio, and cardiac hypertroph

SUBMITTER: Li S 

PROVIDER: S-EPMC9370783 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature