Molecular Targets for Antibody-Based Anti-Biofilm Therapy in Infective Endocarditis.

ABSTRACT: Infective endocarditis (IE) is a heart disease caused by the infection of heart valves, majorly caused by Staphilococcus aureus. IE is initiated by bacteria entering the blood circulation in favouring conditions (e.g., during invasive procedures). So far, the conventional antimicrobial strategies based on the usage of antibiotics remain the major intervention for treating IE. Nevertheless, the therapeutic efficacy of antibiotics in IE is limited not only by the bacterial drug resistance, but also by the formation of biofilms, which resist the penetration of antibiotics into bacterial cells. To overcome these drawbacks, the development of anti-biofilm treatments that can expose bacteria and make them more susceptible to the action of antibiotics, therefore resulting in reduced antimi

SUBMITTER: Han J 

PROVIDER: S-EPMC9370930 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature