L-Arginine-Derived Polyamidoamine Oligomers Bearing at Both Ends β-Cyclodextrin Units as pH-Sensitive Curcumin Carriers.

ABSTRACT: The aza-Michael polyaddition of L-arginine and N,N'-methylene-bis-acrylamide gives the biocompatible and easily cell-internalized polyamidoamine ARGO7. By controlled synthesis, two ARGO7 oligomers, namely a trimer and a pentamer, bearing acrylamide terminal units, were obtained as precursors of the β-cyclodextrin-end-terminated oligomers P3 and P5, which have been shown to encapsulate curcumin at both pH 7.4 and 4.5. After lyophilization, P3- and P5-curcumin complexes gave stable water solutions. The apparent solubility of encapsulated curcumin was in the range 20-51 μg mL^-1, that is, three orders of magnitude higher than the water solubility of free curcumin (0.011 μg mL^-1). The drug release profiles showed induction periods both at pH levels 4.5 and 7.

SUBMITTER: Treccani S 

PROVIDER: S-EPMC9371169 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature