Role of serine/threonine protein phosphatase PrpN in the life cycle of Bacillus anthracis.

ABSTRACT: Reversible protein phosphorylation at serine/threonine residues is one of the most common protein modifications, widely observed in all kingdoms of life. The catalysts controlling this modification are specific serine/threonine kinases and phosphatases that modulate various cellular pathways ranging from growth to cellular death. Genome sequencing and various omics studies have led to the identification of numerous serine/threonine kinases and cognate phosphatases, yet the physiological relevance of many of these proteins remain enigmatic. In Bacillus anthracis, only one ser/thr phosphatase, PrpC, has been functionally characterized; it was reported to be non-essential for bacterial growth and survival. In the present study, we characterized another ser/thr phosphatase (PrpN) of B. anthrac

SUBMITTER: Gangwal A 

PROVIDER: S-EPMC9371265 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature