Association between folic acid use during pregnancy and gestational diabetes mellitus: Two population-based Nordic cohort studies.

ABSTRACT:

Introduction

Inconsistent results have been reported on the association between folic acid use in pregnancy and risk of GDM. The aim of this study was to estimate the association between folic acid use and GDM in two population-based Nordic cohorts.

Material and methods

Two cohort studies were conducted using data from the national population registers in Norway (2005-2018, n = 791,709) and Sweden (2006-2016, n = 1,112,817). Logistic regression was used to estimate the associations between GDM and self-reported folic acid use and prescribed folic acid use, compared to non-users, adjusting for covariates. To quantify how potential unmeasured confounders may affect the estimates, E-values were reported. An exposure misclassification bias analysis was also performed.

Results

SUBMITTER: Pazzagli L 

PROVIDER: S-EPMC9371283 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature