Single-cell measurement quality in bits.

ABSTRACT: Single-cell measurements have revolutionized our understanding of heterogeneity in cellular response. However, there is no universally comparable way to assess single-cell measurement quality. Here, we show how information theory can be used to assess and compare single-cell measurement quality in bits, which provides a universally comparable metric for information content. We anticipate that the experimental and theoretical approaches we show here will generally enable comparisons of quality between any single-cell measurement methods.

SUBMITTER: Rammohan J 

PROVIDER: S-EPMC9371318 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature