A Bayesian network analysis quantifying risks versus benefits of the Pfizer COVID-19 vaccine in Australia.

ABSTRACT: The Pfizer COVID-19 vaccine is associated with increased myocarditis incidence. Constantly evolving evidence regarding incidence and case fatality of COVID-19 and myocarditis related to infection or vaccination, creates challenges for risk-benefit analysis of vaccination. Challenges are complicated further by emerging evidence of waning vaccine effectiveness, and variable effectiveness against variants. Here, we build on previous work on the COVID-19 Risk Calculator (CoRiCal) by integrating Australian and international data to inform a Bayesian network that calculates probabilities of outcomes for the delta variant under different scenarios of Pfizer COVID-19 vaccine coverage, age groups (≥12 years), sex, community transmission intensity and vaccine effectiveness. The model estimates that

SUBMITTER: Sinclair JE 

PROVIDER: S-EPMC9371378 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature