CircRNA expression profile and potential role of hsa_circ_0040039 in intervertebral disc degeneration.

ABSTRACT:

Purpose

Circular RNAs (circRNAs) play an critical role in the pathological processes associated with IDD. However, the potential roles of circRNAs in IDD remain largely unclear. Here, we identify the circRNAs expression profiles and elucidate the potential role of candidate circRNAs in the pathogenesis of intervertebral disc degeneration (IDD) through microarray data and bioinformatics analyses.

Methods

We obtained the datasets of microarrays (GSE67566 and GSE116726) from the Gene Expression Omnibus database. The differentially expressed circRNAs and miRNAs were identified using the Limma R package. The target miRNAs and target genes of the candidate circRNAs were predicted using an online tool. Functional enrichment analyses of the target genes were performed using the clus

SUBMITTER: Huang S 

PROVIDER: S-EPMC9371492 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature