Identify differential inflammatory cellular and serology pathways between children and adult patients in the lupus registry.

ABSTRACT:

Background

Age variances in systemic lupus erythematosus (SLE) may reflect different patterns and consequences. Monocyte differentiation is critical, and cytokine and chemokine milieu may be associated with long term outcome and treatment responses. This study aims to evaluate the inflammatory cellular and serology pathways associated with age in our lupus registry.

Methods

We included patients with SLE and divided them into 2 groups according to age, ≤18 or >18 years old. We performed flow cytometry analysis to define the peripheral blood monocyte differentiation pattern and phenotypes and used the multiplex method to detect cytokine and chemokine panels. The results were then compared between the 2 subgroups.

Results

In total, 47 SLE patients were included in this s

SUBMITTER: Hsu CY 

PROVIDER: S-EPMC9371509 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature