Multiple types of navigational information are independently encoded in the population activities of the dentate gyrus neurons.

ABSTRACT: The dentate gyrus (DG) plays critical roles in cognitive functions, such as learning, memory, and spatial coding, and its dysfunction is implicated in various neuropsychiatric disorders. However, it remains largely unknown how information is represented in this region. Here, we recorded neuronal activity in the DG using Ca²⁺ imaging in freely moving mice and analyzed this activity using machine learning. The activity patterns of populations of DG neurons enabled us to successfully decode position, speed, and motion direction in an open field, as well as current and future location in a T-maze, and each individual neuron was diversely and independently tuned to these multiple information types. Our data also showed that each type of information is unevenly distributed in groups o

SUBMITTER: Murano T 

PROVIDER: S-EPMC9371651 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature