The structure and activities of the archaeal transcription termination factor Eta detail vulnerabilities of the transcription elongation complex.

ABSTRACT: Transcription must be properly regulated to ensure dynamic gene expression underlying growth, development, and response to environmental cues. Regulation is imposed throughout the transcription cycle, and while many efforts have detailed the regulation of transcription initiation and early elongation, the termination phase of transcription also plays critical roles in regulating gene expression. Transcription termination can be driven by only a few proteins in each domain of life. Detailing the mechanism(s) employed provides insight into the vulnerabilities of transcription elongation complexes (TECs) that permit regulated termination to control expression of many genes and operons. Here, we describe the biochemical activities and crystal structure of the superfamily 2 helicase Eta, one of

SUBMITTER: Marshall CJ 

PROVIDER: S-EPMC9371683 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature